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Listar por autor "Huertas Sánchez, Pablo"
Mostrando ítems 1-20 de 49
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Artículo
A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection
López Saavedra, Ana; Gómez Cabello, Daniel; Domínguez Sánchez, María Salud; Mejías Navarro, Fernando; Fernández Ávila, María Jesús; Martínez Macías, María Isabel; Huertas Sánchez, Pablo (Nature Publishing Group, 2016)There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous ...
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Artículo
ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
Jimeno González, Sonia; Prados Carvajal, Rosario; Fernández Ávila, María Jesús; Pinela Da Silva, Sonia Cristina; Silvestris, Domenico Alessandro; Endara Coll, Martin; Rodríguez Real, Guillermo; Domingo Prim, Judit; Mejías Navarro, Fernando; Romero Franco, Amador; Jimeno González, Silvia; Barroso, Sonia; Cesarini, Valeriana; Aguilera López, Andrés; Gallo, Angela; Visa, Neus; Huertas Sánchez, Pablo (Nature Publishing Group, 2021)The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA ...
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Artículo
ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection
Mejías Navarro, Fernando; Rodríguez Leal, Jesús M.; Ramón, Javier; Camarillo Daza, María Rosa; Huertas Sánchez, Pablo (Public Library of Science, 2020)During repair of DNA double-strand breaks, resection of DNA ends influences how these lesions will be repaired. If resection ...
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Artículo
An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination
Huertas Sánchez, Pablo; García Rubio, María Luisa; Wellinger, Ralf Erik; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Microbiology, 2006)THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ...
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Artículo
BRCA1 Accelerates CtIP-Mediated DNA-End Resection
Cruz García, Andrés; López Saavedra, Ana; Huertas Sánchez, Pablo (Elsevier, 2014)DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In ...
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Artículo
Cationic Single-Chained Surfactants with a Functional Group at the End of the Hydrophobic Tail DNA Compacting Efficiency
Lebrón Romero, José Antonio; López-Cornejo, María del Pilar; García Dionisio, Elena; Huertas Sánchez, Pablo; García Calderón, Margarita; Moyá Morán, María Luisa; Ostos Marcos, Francisco José; López López, Manuel (Multidisciplinary Digital Publishing Institute (MDPI), 2021)The interaction between calf-thymus DNA, ctDNA, and various single-chained surfactants with different functional groups ...
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Artículo
CDK targets Sae2 to control DNA-end resection and homologous recombination
Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Sartori, Alessandro A.; Aguilera López, Andrés; Jackson, Stephen P. (Nature Publishing Group, 2008)DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ...
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Artículo
Centriolar Subdistal Appendages Promote Double-strand Break Repair Through Homologous Recombination
Rodriguez Real, Guillermo; Domínguez Calvo, Andrés; Prados Carvajal, Rosario; Bayona Feliu, Aleix; Gomes Pereira, Sonia; Romero Balestra, Fernando; Huertas Sánchez, Pablo (1469-3178, 2023)The centrosome is a cytoplasmic organelle with roles in microtu-bule organization that has also been proposed to act as a ...
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Artículo
Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination
Muñoz Galván, Sandra; López Saavedra, Ana; Jackson, Stephen P.; Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Aguilera López, Andrés (Oxford University Press, 2013)While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ...
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Tesis Doctoral
Control de la procesividad de la resección por las proteinas CTIP, BRCA1 y las topoisomerasas del tipo II
Cruz García, Andrés (2017-01-16)Las cadenas de ADN pueden sufrir roturas debido a la acción de agentes exógenos, principalmente mutágenos químicos o ...
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Tesis Doctoral
Crosstalk between DNA end resection and RNA metabolism
Prados Carvajal, Rosario (2020-01-23)DNA suffers thousands of lesions from exogenous and endogenous sources. Nevertheless, double-strand breaks (DSBs) are the ...
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Artículo
CtIP Mutations Cause Seckel and Jawad Syndromes
Qvist, Per; Huertas Sánchez, Pablo; Jimeno González, Sonia; Nyegaard, Mette; Hassan, Muhammad J.; Jackson, Stephen P. (Public Library of Science, 2011)Seckel syndrome is a recessively inherited dwarfism disorder characterized by microcephaly and a unique head profile. ...
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Artículo
CtIP-mediated Alternative mRNA Splicing Fine-tunes the DNA Damage Response
Prados Carvajal, Rosario; Rodríguez Real, Guillermo; Gutiérrez Pozo, Gabriel; Huertas Sánchez, Pablo (Cold Spring Harbor Laboratory Press, 2021)In order to survive to the exposure of DNA damaging agents, cells activate a complex response that coordinates the cellular ...
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CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells
Gómez Cabello, Daniel; Checa Rodríguez, Cintia; Abad, María; Serrano, Manuel; Huertas Sánchez, Pablo (Elsevier, 2017)Acquired genomic instability is one of the major concerns for the clinical use of induced pluripotent stem cells (iPSCs). ...
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Artículo
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
Hernández, Gonzalo; Ramirez, María José; Minguillón, Jordi; Quiles, Paco; Huertas Sánchez, Pablo; Prados Carvajal, Rosario (Nature Publishing Group, 2018)BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated ...
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Artículo
DNA end resection requires constitutive sumoylation of CtIP by CBX4
Soria Bretones, Isabel; Cepeda García, Cristina; Checa Rodríguez, Cintia; Heyer, Vincent; Reina San Martín, Bernardo; Soutoglou, Evi; Huertas Sánchez, Pablo (Nature Publishing Group, 2017)DNA breaks are complex DNA lesions that can be repaired by two alternative mechanisms: non-homologous end-joining and ...
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Artículo
DNA resection in eukaryotes: deciding how to fix the break
Huertas Sánchez, Pablo (Natural Research, 2010)DNA double-strand breaks are repaired by different mechanisms, including homologous recombination and nonhomologous ...
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Artículo
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
Domingo Prim, Judit; Endara Coll, Martin; Bonath, Franziska; Prados Carvajal, Rosario; Friedländer, Marc R.; Visa, Neus; Huertas Sánchez, Pablo; Jimeno González, Sonia (Nature Research, 2019)The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is ...
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Artículo
Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair
Huertas Sánchez, Pablo; Jackson, Stephen P. (American Society for Biochemistry and Molecular Biology, 2009)In G0 and G1, DNA double strand breaks are repaired by nonhomologous end joining, whereas in S and G2, they are also repaired ...
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Tesis Doctoral
Identificación de nuevas proteínas que interaccionan con CtIP: Implicación de PRMT5 y CCAR2 en la resección del ADN
López Saavedra, Ana (2017-06-06)DNA double-strand breaks (DSBs) represent the most cytotoxic DNA lesion that can arise from either endogenous and exogenous ...